From Fresno go east on Highway 168. From Madera and locations north, cross on Highway 145, then go past Millerton Lake and up to intersect Highway 168 in Prather. Fill up on gas along the way in Prather or Shaver Lake. Continue on Highway 168 past Shaver Lake to Huntington Lake. There Highway 168 ends.
Turn right onto Kaiser Pass Road. Large RVs and trailers are not recommended on this road. Be prepared for narrow sections where you may have to pull over into a turnout to let oncoming traffic pass. Follow the road 7 miles to the top of Kaiser Pass and then on down the other side another 10 miles to an intersection. To the left the road leads to Lake Edison. Stay to the right. 6 more miles will deliver you to Florence Lake.
If you plan to stay very long, use the large upper parking lot, rather than the temporary parking spaces by the store.
The road closes for the winter at the first major snowfall, usually in late October or early November. It reopens in May on most years, but heavy snow can delay the opening.