From Fresno go east on Highway 168. From Madera and locations north, cross on Highway 145, then go past Millerton Lake and up to intersect Highway 168 in Prather. Fill up on gas along the way in Prather or Shaver Lake. Continue on Highway 168 past Shaver Lake to Huntington Lake. There Highway 168 ends.
Turn right onto Kaiser Pass Road. Large RVs and trailers are not recommended on this road. Be prepared for narrow sections where you may have to pull over into a turnout to let oncoming traffic pass. Follow the road 7 miles to the top of Kaiser Pass and then on down the other side another 10 miles to a left turn onto the Lake Thomas A. Edison road. 6 more miles will bring you to the lake.
Driving times show below can vary based on road conditions. Friday and Sunday afternoons can be busy on Kaiser Pass Road.